Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 18, 2008
Patent Application Number
09612914
Date Filed
July 10, 2000
Patent Primary Examiner
Patent abstract
Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties including low antigenicity, reduced (or absent) T cell depleting activity, good affinity to human CD4 and enhanced stability (in vivo half-life).
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