Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Xianxhang Yu0
Thomas E. Wagner0
Date of Patent
November 25, 2008
0Patent Application Number
099386230
Date Filed
August 27, 2001
0Patent Primary Examiner
Patent abstract
A cytotoxin can be rendered non-toxic by charge neutralizing the amino acids salient to pore assembly and/or sterically inhibiting formation of the peptide's active conformation. In the presence of specific proteases, the inactive peptide or procytotoxin can be activated to assemble into its lytic conformation and selectively destroy a target cell.
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