Patent 7459455 was granted and assigned to Smithkline Beecham Limited on December, 2008 by the United States Patent and Trademark Office.
Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.