Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
December 2, 2008
Patent Application Number
10894834
Date Filed
July 20, 2004
Patent Primary Examiner
Patent abstract
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
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