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US Patent 7476651 Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis

Patent 7476651 was granted and assigned to the scripps research institute on January, 2009 by the United States Patent and Trademark Office.

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Patent abstract

The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.

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