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US Patent 7476692 Pharmaceutical compositions of safingol and methods of using the same

Patent 7476692 was granted and assigned to CHILDRENS HOSPITAL LOS ANGELES on January, 2009 by the United States Patent and Trademark Office.

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Current Assignee
CHILDRENS HOSPITAL LOS ANGELES
CHILDRENS HOSPITAL LOS ANGELES
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
7476692
Date of Patent
January 13, 2009
Patent Application Number
10782459
Date Filed
February 19, 2004
Patent Primary Examiner
‌
Raymond J. Henley, III
Patent abstract

The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about 0.1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0.2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.

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