A reverse-phase cross coupling structure includes a base, which has a resonance chamber, resonators vertically arranged in parallel in the resonance chamber, and coupling portions respectively coupled between each two adjacent resonators, each coupling portion having a top recess and a coupling hole in the top recess, and an adjustment device, which comprises a cover plate fixedly covered on the base and has through holes corresponding to the coupling holes of the coupling portions and a plurality of adjustment screws respectively inserted through the through holes of the cover plate and threaded into the coupling holes of the coupling portions to the desired elevation to regulate the amount of the reverse-phase cross coupling of the resonators. This novel reverse-phase cross coupling structure is achieved only by base and adjustment device, it is not necessary to employ extra parts as in the prior designs.