The invention relates to the field of transplantation medicine and to the prevention and treatment of rejection, in particular of chronic rejection, of a transplant by a recipient of the transplant. The invention provides method for modulating transplant survival in a recipient of the transplant comprising providing the transplant with a gene-regulatory peptide or functional analogue thereof. Furthermore, the invention provides use of a gene-regulatory peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of a transplant allowing modulating transplant survival in a recipient of the transplant.