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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Seetharama A. Acharya0
Belur N. Manjula0
Date of Patent
March 10, 2009
Patent Application Number
10538976
Date Filed
December 18, 2003
Patent Primary Examiner
Patent abstract
The present invention provides a hemoglobin molecule (Hb) having six ± one PEG chains, wherein two of said PEG chains are bound to Cys-93 (β) of Hb, and the remaining PEG chains are bound to thiol groups introduced on ε-NH2 of Hb. The present invention also provides a process for preparing a modified hemoglobin molecule (Hb), comprising the steps of: (a) reacting Hb with 8-15 fold excess of iminothiolane to form thiolated Hb; and (b) reacting the thiolated Hb with 16-30 fold excess of PEG functionalized with a maleimide moiety, to form the modified Hb.
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