Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ronen Tchelet0
Lorand Szabo0
Date of Patent
March 17, 2009
0Patent Application Number
112951420
Date Filed
December 5, 2005
0Patent Primary Examiner
Patent abstract
The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to express both cytochrome P-450 and the fdxshe or fdxshe-like protein. The invention further relates to the use of such microorganisms in processes designed for production of pravastatin for use in treatment of disease such as hypercholesterolemia and hyperlipidemia.
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