A moisture-proof sealing bag comprises a bag body and an exhausting valve. The bag body has an opening, which has a flexible belt on the opening end. A proper position under the flexible belt of the bag body has the exhausting valve. The exhausting valve is concealed inner the bag body, which comprises a valve body, an exhausting unit, a valve gate and an elastomer. The moisture-proof sealing bag has functions of moisture-proof and air-tightness so as to preserve the contents in the bag by use of sealing the opening of the bag with the flexible belt and exhausting the residual air with the exhausting valve.