There is disclosed a control system of an injection molding machine in which a controller mounted on a main body side of an injection molding machine comprises a data memory having a memory area to always reflect information regarding a plurality of operation conditions and operation situations corresponding to peripheral devices, and a program to give a desired command to the peripheral devices, and a control section of the peripheral devices and the controller on the injection molding machine main body side comprise a data transmission line to always reflect information regarding the operation conditions and the operation situations, and a transmission control section equipped with a protocol regarding a signal transmitted through the transmission line.