Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Nobuhiro Ito0
Hironao Sajiki0
Kazushige Muto0
Kosaku Hirota0
Tsuneaki Maesawa0
Date of Patent
April 14, 2009
Patent Application Number
10534344
Date Filed
November 7, 2003
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent.
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