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US Patent 7521211 IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof

Patent 7521211 was granted and assigned to Regeneron Pharmaceuticals, Inc. on April, 2009 by the United States Patent and Trademark Office.

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Patent abstract

A chimeric protein comprising an IGF1 and an IGF2 component and optionally a fusion component (F) and/or a signal sequence, exhibiting improved activity relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound.

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