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US Patent 7531318 Screening of agents for activity against ischemic myocardial insults

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Ankur Saxena0

Deepak Srivastava0

Ildiko Bock-Marquette0

Date of Patent

May 12, 2009

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Patent Application Number

112091990

Date Filed

August 22, 2005

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Patent Citations Received

US Patent 12122819 Method of treating skin tissue damage by topically administering a bi-specific protein comprising a human insulin-like growth factor variant and a human annexin A5 variant

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US Patent 11673970 Bi-specific fusion proteins

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US Patent 11879002 Bi-specific therapeutic proteins, in vivo methods of use thereof and encoding nucleic acids thereof

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Patent Primary Examiner

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Patent abstract

Integrin-linked kinase (ILK) and Akt/protein kinase B (PKB) are important mediators of signaling in cardiomyocytes and can both prevent damage and promote healing associated with ischemic injury to the heart. Thus, the present invention provides for methods of screening for agents that increase the expression of ILK and/or Akt/PKB. Methods of treatment based on such agents are also provided.

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