US Patent 7544657 Stabilized Exendin-4 compounds
Patent 7544657 was granted and assigned to Zealand Pharma A/S on June, 2009 by the United States Patent and Trademark Office.
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The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, or isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds, such as for the treatment of diabetes.
US Patent 07544657 Stabilized Exendin-4 compounds US Patent 7544657 Stabilized Exendin-4 compounds
US Patent 07544657 Stabilized Exendin-4 compounds
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