US Patent 7553627 Process for high throughput DNA methylation analysis
Patent 7553627 was granted and assigned to University of Southern California on June, 2009 by the United States Patent and Trademark Office.
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There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite to create methylation-dependent sequence differences, followed by detection with fluorescence-based quantitative PCR techniques. The process is particularly well suited for the rapid analysis of a large number of nucleic acid samples, such as those from collections of tumor tissues.
US Patent 07553627 Process for high throughput DNA methylation analysis US Patent 7553627 Process for high throughput DNA methylation analysis
US Patent 07553627 Process for high throughput DNA methylation analysis
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