A multi compartment reclosable plastic bag including four or more panels sealed together to form at least two bags with each bag having a resealable opening. One of the bags may be smaller than the other(s). The plastic bags further include lips that are adjacent to the resealable openings. The bags incorporate closure elements for sealing and unsealing of the resealable openings. The smaller bag may include a lip that folds toward the space between the smaller bag and an adjacent bag to form a cuff portion adapted to secure contents inserted between the smaller bag and the adjacent bag.