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US Patent 7556817 Clostridial toxin activatable Clostridial toxins

Patent 7556817 was granted and assigned to Allergan, Inc. on July, 2009 by the United States Patent and Trademark Office.

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Patent abstract

The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate cleavage site located within the di-chain loop region.

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