A leakproof perfume spray head structure comprises a spray head, a locking shell, an inner sleeve, a rotation shaft, a water guide pipe, and an outer cover, wherein the spray head has gaps for better communicating the gas with the perfume liquid so as to spray out more uniform perfume mists. When the spray head is opened, but not in use, the spray head can be rotated by a certain angle so as to close the inner spray tunnel of the spray head completely to prevent the perfume liquid from leakage.