US Patent 7560235 Method of detecting reaction of DNA and DNA-binding protein
Patent 7560235 was granted and assigned to Olympus Group on July, 2009 by the United States Patent and Trademark Office.
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In the case of detecting whether or not a binding site of a transcription factor TFIID and a transcription factor TFIIB is present in a labeled DNA, the presence of a binding site can be detected precisely by adding all of a transcription factor TFIID, a transcription factor TFIIB and an anti-TFIIB antibody to a DNA-containing solution, and obtaining a translational diffusion time of the binding product by FCS-measurement. Information for obtaining a translational diffusion time is obtained, by mixing the sample and measuring it by fluorescence correlation spectroscopy (FCS), and as a result, detection result can be simply obtained in a short time, without performing troublesome operation such as utilization of a radioisotope and selection by an electrophoresis method or immobilization of a molecule on a solid substrate.
US Patent 07560235 Method of detecting reaction of DNA and DNA-binding protein US Patent 7560235 Method of detecting reaction of DNA and DNA-binding protein
US Patent 07560235 Method of detecting reaction of DNA and DNA-binding protein
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