Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Wolfgang Skranc0
Karl Gruber0
Roland Weis0
Ruud Luiten0
Anton Glieder0
Date of Patent
August 11, 2009
0Patent Application Number
105482710
Date Filed
February 24, 2004
0Patent Primary Examiner
Patent abstract
The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.
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