Patent 7572614 was granted and assigned to Academia Sinica on August, 2009 by the United States Patent and Trademark Office.
A crystalline structure of glutaminyl cyclase (QC). is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat QC-associated disorders is also described.