Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jiang Chang0
Robert J. Schwartz0
Mark Entman0
Lei Wei0
Date of Patent
September 1, 2009
0Patent Application Number
107630370
Date Filed
January 22, 2004
0Patent Primary Examiner
Patent abstract
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.
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