Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Christopher Carl Frye0
Radmila Micanovic0
Lihua Huang0
Date of Patent
September 1, 2009
0Patent Application Number
115743320
Date Filed
July 26, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced capacity of O-glycosylation when expressed in yeast compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.
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