Patent 7588942 was granted and assigned to Bio-Rad Laboratories on September, 2009 by the United States Patent and Trademark Office.
A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a red blood cell lysate that is free of plasma, leukocytes, and platelets with a platelet-free plasma of human origin and an antimicrobial agent.