Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
September 15, 2009
Patent Application Number
09914451
Date Filed
February 28, 2000
Patent Primary Examiner
Patent abstract
The present invention relates to an isolated leukotriene A4 (LTA4) hydrolase, which LTA4 hydrolase is present in its naturally occurring three dimensional form. It is the first three-dimensional structure of any protein component of the leukotriene cascade and enables a description of the structural basis and molecular mechanisms for the two catalytic activities of LTA4 hydrolase. Further, the invention also relates to LTA4 hydrolase complexed with an inhibitor. The structural information provided by the present invention will make possible rational design of enzyme inhibitors, which may be developed into clinically useful anti-inflammatory drugs.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
