Patent 7592147 was granted and assigned to President and Fellows of Harvard College on September, 2009 by the United States Patent and Trademark Office.
The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.