Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Steven Gary Kendrew0
Hrvoje Petkovic0
Peter Francis Leadlay0
Date of Patent
September 29, 2009
Patent Application Number
10344738
Date Filed
August 14, 2001
Patent Primary Examiner
Patent abstract
Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
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