Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Angela Reynolds0
Anastasia Khvorova0
Devin Leake0
Peter S. Linsley0
William Marshall0
Date of Patent
September 29, 2009
0Patent Application Number
110198310
Date Filed
December 22, 2004
0Patent Citations Received
0
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Patent Primary Examiner
Patent abstract
Methods and compositions for performing RNA interference with decreased off-target effects are provided The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2′-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
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