US Patent 7598222 Process for solubilizing glucagon-like peptide 1 compounds
Patent 7598222 was granted and assigned to Eli Lilly and Company on October, 2009 by the United States Patent and Trademark Office.
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Patent Inventor Names
Joseph Vincent Rinella, Jr.0
Walter Francis Prouty, Jr.0
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Patent abstract
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
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US Patent 07598222 Process for solubilizing glucagon-like peptide 1 compounds US Patent 7598222 Process for solubilizing glucagon-like peptide 1 compounds
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Patent Number
07598222
Patent Number
7598222
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Official Website
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US Patent 07598222 Process for solubilizing glucagon-like peptide 1 compounds
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Is a
Current assignee
Patent jurisdiction
Patent number
07598222
Date of patent
October 6, 2009
Patent application number
10169657
Date Filed
January 16, 2001
Patent primary examiner
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