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US Patent 7598370 siRNA targeting polo-like kinase-1 (PLK-1)

Patent 7598370 was granted and assigned to Dharmacon, Inc. on October, 2009 by the United States Patent and Trademark Office.

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Patent abstract

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to PLK-1.

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