Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vittoria Cioce0
Paul T. Wingfield0
Stephen J. Stahl0
Stuart A. Aaronson0
Andrew M. L. Chan0
Donald P. Bottaro0
Jeffrey S. Rubin0
Date of Patent
October 20, 2009
0Patent Application Number
102837690
Date Filed
October 30, 2002
0Patent Primary Examiner
Patent abstract
The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
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