Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
G. Mark Anderson0
Michael Naso0
Ann Cai0
Bernard Scallon0
Cam Ngo0
Date of Patent
October 20, 2009
0Patent Application Number
110107970
Date Filed
December 13, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.
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