Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kallanthottathil G. Rajeev0
Muthiah Manoharan0
Venkitasamy Kesavan0
Date of Patent
December 1, 2009
0Patent Application Number
111159890
Date Filed
April 27, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improves the pharmacokinetic properties of the oligonucleotides. The aralkyl ligands of the present invention include naproxen, ibuprofen and derivatives thereof. The present invention also provides methods for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
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