Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
December 8, 2009
Patent Application Number
10761557
Date Filed
January 21, 2004
Patent Primary Examiner
Patent abstract
The present invention provides compositions and methods for the manipulation of ion channels. For example, the present invention relates to Parkinson's and other neurological diseases and conditions, and treatments thereof. In particular, the present invention provides methods of decreasing pathophysiological high frequency neuronal bursts of Parkinson's and other neurological diseases and conditions. Methods of the present invention comprise decreasing Kv3 ion channel activity in fast-spiking neurons, including by decreasing activity of a Kv3.4 protein and by specifically targeting a Kv3.4 protein with an inhibitor.
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