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US Patent 7635686 Therapeutically useful triethyleneglycol cholesteryl oligonucleotides

Patent 7635686 was granted and assigned to Bioniche Life Sciences Inc. on December, 2009 by the United States Patent and Trademark Office.

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Current Assignee
‌
Bioniche Life Sciences Inc.
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
7635686
Date of Patent
December 22, 2009
Patent Application Number
10264280
Date Filed
October 3, 2002
Patent Primary Examiner
‌
Sheela J. Huff
Patent abstract

The present invention provides a composition comprising a 5′-OH, 3′-TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. The present invention provides methods of using this composition for induction of response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells or synovial cells, and methods of using this composition for treating disease.

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