US Patent 7642399 Mouse with deficiency of glutamate transporter GLAST function

Patent 7642399 was granted and assigned to Japan Science and Technology Agency on January, 2010 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Japan Science and Technology Agency

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

76423990

Patent Inventor Names

Takayuki Harada0

Kohichi Tanaka0

Date of Patent

January 5, 2010

Patent Application Number

105530510

Date Filed

April 13, 2004

Patent Primary Examiner

‌

Fereydoun G Sajjadi

Patent abstract

The present invention provides a GLAST knockout mouse lacking the function of an endogenous glutamate transporter GLAST gene, which shows: 1) an intraocular pressure within the normal range; and 2) a reduction in the number of cells in the retinal ganglions when compared with a wild-type normal mouse. Owing to the ocular properties, this knockout mouse is useful as a model for normal tension glaucoma. By using this knockout mouse, a compound useful for the treatment of normal tension glaucoma can be screened.

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