Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tae Hyoung Yoo0
Kang In Na0
Moo Young Song0
Sang Koo Park0
Byung Kyu Lee0
Chang Seok Kim0
Heui Il Kang0
Date of Patent
January 12, 2010
Patent Application Number
11722094
Date Filed
December 29, 2005
Patent Primary Examiner
Patent abstract
Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.
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