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US Patent 7645603 Cells having cardiac glycoside resistance

Patent 7645603 was granted and assigned to Avaris on January, 2010 by the United States Patent and Trademark Office.

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Patent abstract

An isolated cell having a nucleic acid construct encoding a recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g., ouabain, is disclosed. Selected amino acid substitutions in the normal human Na+, K+-ATPase α1-subunit confers resistance to cardiac glycosides. Cardiac glycoside resistant Na+, K+-ATPase α1-subunits may be useful as selection markers in gene therapy and research applications.

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