Patent 7655445 was granted and assigned to Massachusetts Institute of Technology on February, 2010 by the United States Patent and Trademark Office.
The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the synthesis of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides.