Disclosed is a methodology for deriving data related to various selected tire (10) conditions. One or more sensors are analyzed in a manner similar to that of analyzing an electro-cardiogram taken from a human patient in order to determine selected operational characteristics of the monitored tires (10). Analysis of the signal waveforms may involve analysis of a single waveform and/or comparison of paired waveforms originating for sensors associated with a single tire or paired tires (10).