Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Josephine M. Cardarelli0
Mohan Srinivasan0
Alison Witte0
Date of Patent
February 16, 2010
0Patent Application Number
111574940
Date Filed
June 20, 2005
0Patent Primary Examiner
Patent abstract
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
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