Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Silviu Itescu0
Date of Patent
February 16, 2010
0Patent Application Number
105124960
Date Filed
April 23, 2003
0Patent Primary Examiner
Patent abstract
The present invention provides DNAzymes and ribozymes that specifically cleave PAI-1-encoding mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of PAI-1-encoding mRNA. The invention also provides various methods of inhibiting the expression of PAI-1, and methods of treating diseases by such. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes, antisense oligonucleotides, or other inhibitors of PAI-1 expression as active ingredients.
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