Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 23, 2010
Patent Application Number
11755936
Date Filed
May 31, 2007
Patent Primary Examiner
Patent abstract
Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomolytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
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