An arrangement is described for compensating intra-channel nonlinearities in an optical communications system which combines optical dispersion compensation with electronic pre-distortion (EPD). EPD with moderate lookup table size can effectively suppress intra-channel nonlinearities over optical transmission links incorporating optical dispersion compensation. The arrangement can be implemented for a variety of optical communications systems, including 10 Gb/s, 40 Gb/s and higher bit rate systems as well as single-channel and wavelength-division multiplexing (WDM) systems.