Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 16, 2010
Patent Application Number
11797992
Date Filed
May 9, 2007
Patent Primary Examiner
Patent abstract
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy groups and/or non-methylated nitrogen atoms in position α and/or any other acid group capable of deprotonation which are optionally deprotonated or in protected form.
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