Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Peter Turecek0
Herbert Gritsch0
Juergen Siekmann0
Katalin Varadi0
Date of Patent
March 23, 2010
0Patent Application Number
117296250
Date Filed
March 29, 2007
0Patent Primary Examiner
Patent abstract
The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
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