Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeannie M. Arruda0
Benito Munoz0
Brian A. Stearns0
Date of Patent
March 30, 2010
0Patent Application Number
105746550
Date Filed
October 18, 2004
0Patent Primary Examiner
Patent abstract
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more soluble in aqueous media than the active agents into which they convert, in vivo. As such compounds of Formula (I) and (II) are advantageous for, among other things intravenous administration. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) and Formula (II).
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