Self-timed interfaces and methods for interfacing different timing domains. These self-timed interfaces receive a strobe signal from a component operating under a first clock domain. A first signal path of the self-timed interface couples the strobe signal to a receiver that samples data of data line under control of the strobe signal. A second signal path of the self-timed interface couples the strobe signal to an interface circuit through a hysteresis-based element. The interface circuit, under control of an output of the hysteresis-based element along with a clock signal that originates under a second clock domain, generates an interface enable signal for use in controlling data transfers between the different clock domains.